Research & Initiatives

Our lab focuses on using neuromodulation technology (including deep brain stimulation (DBS), spinal cord stimulation (SCS), responsive neurostimulation (RNS), trigeminal nerve stimulation (TNS), transcranial magnetic stimulation (TMS), and radiomodulation) to better understand underlying mechanisms and optimize treatments of various neuropsychiatric disorders. We use a multidisciplinary approach by integrating neuromodulation with electrophysiological, neuroimaging, computational, bioinformatics, and optical information in research and clinical settings. Current research projects include studies on depression, Parkinson's, obsessive-compulsive disorder, epilepsy, pain, normal pressure hydrocephalus, and Alzheimer's.

We are based in the Center of Functional Neurosurgery at Zhejiang University School of Medicine Second Affiliated Hospital in Hangzhou, China.

Selected Publications

Yu Q, Zhu J, Wu H. Traumatic Brain Injury, Bulging Eyeball, and Skin Lumps. World Neurosurg. 2022 Sep 27:S1878-8750(22)01371-7. doi: 10.1016/j.wneu.2022.09.093.

Yu Q, Guo X, Zhu Z, Feng C, Jiang H, Zheng Z, Zhang J, Zhu J, Wu H. White Matter Tracts Associated With Deep Brain Stimulation Targets in Major Depressive Disorder: A Systematic Review. Front Psychiatry. 2022 Apr 28;13:806916. doi: 10.3389/fpsyt.2022.806916.

Zheng Z, Zhu Z, Ying Y, Jiang H, Wu H, Tian J, Luo W, Zhu J. The Accuracy of Imaging Guided Targeting with Microelectrode Recoding in Subthalamic Nucleus for Parkinson's Disease: A Single-Center Experience. J Parkinsons Dis. 2022;12(3):897-903. doi: 10.3233/JPD-213095.

Zhu Z, Hubbard E, Guo X, Barbosa DAN, Popal AM, Cai C, Jiang H, Zheng Z, Lin J, Gao W, Zhang J, Bartas K, Macchia D, Derdeyn P, Halpern CH, Mayberg HS, Beier KT, Zhu J, Wu H. A connectomic analysis of deep brain stimulation for treatment-resistant depression. Brain Stimul. 2021 Sep-Oct;14(5):1226-1233. doi: 10.1016/j.brs.2021.08.010.

Bian S, Tao Y, Zhu Z, Zhu P, Wang Q, Wu H, Sawan M. On-Site Biolayer Interferometry-Based Biosensing of Carbamazepine in Whole Blood of Epileptic Patients. Biosensors (Basel). 2021 Dec 15;11(12):516. doi: 10.3390/bios11120516.

Zheng Y, Ming WJ, Zheng Z, Jiang HJ, Chen C, Wu H, Wang ZJ, Xu SS, Zhu JM, Ding MP, Wang S, Ding Y. Pearls & Oy-sters: Parietal Lobe Epilepsy in Disguise: Motor Attacks Induced by Proprioceptive Triggers. Neurology. 2022 Mar 22;98(12):509-513. doi: 10.1212/WNL.0000000000200050.

Wu H, Hariz M, Visser-Vandewalle V, Zrinzo L, Coenen VA, Sheth SA, Bervoets C, Naesström M, Blomstedt P, Coyne T, Hamani C, Slavin K, Krauss JK, Kahl KG, Taira T, Zhang C, Sun B, Toda H, Schlaepfer T, Chang JW, Régis J, Schuurman R, Schulder M, Doshi P, Mosley P, Poologaindran A, Lázaro-Muñoz G, Pepper J, Schechtmann G, Fytagoridis A, Huys D, Gonçalves-Ferreira A, D'Haese PF, Neimat J, Broggi G, Vilela-Filho O, Voges J, Alkhani A, Nakajima T, Richieri R, Djurfeldt D, Fontaine P, Martinez-Alvarez R, Okamura Y, Chandler J, Watanabe K, Barcia JA, Reneses B, Lozano A, Gabriëls L, De Salles A, Halpern CH, Matthews K, Fins JJ, Nuttin B. Deep brain stimulation for refractory obsessive-compulsive disorder (OCD): emerging or established therapy? Mol Psychiatry. 2021 Jan;26(1):60-65. doi: 10.1038/s41380-020-00933-x.